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Silvia Dei Selected Research

pirarubicin

6/2019Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators.
3/2018Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents.
11/2014Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters.
1/2013New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).
2/2010Structure-activity relationships studies in a series of N,N-bis(alkanol)amine aryl esters as P-glycoprotein (Pgp) dependent multidrug resistance (MDR) inhibitors.
2/2009N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent transporter-dependent multidrug resistance inhibitors.

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Silvia Dei Research Topics

Disease

9Acute Erythroblastic Leukemia (Erythroleukemia)
06/2019 - 02/2005
7Neoplasms (Cancer)
01/2022 - 01/2016
5Breast Neoplasms (Breast Cancer)
12/2020 - 08/2015
3Amnesia (Dissociative Amnesia)
04/2015 - 12/2008
3Neuralgia (Stump Neuralgia)
04/2011 - 01/2004
1Glaucoma
01/2022
1Leukemia
06/2019
1Pathologic Processes
04/2019
1Pain (Aches)
11/2004
1Pheochromocytoma
11/2004

Drug/Important Bio-Agent (IBA)

8Doxorubicin (Adriamycin)FDA LinkGeneric
01/2022 - 02/2009
6pirarubicinIBA
06/2019 - 02/2009
5Proteins (Proteins, Gene)FDA Link
12/2020 - 08/2015
4ATP-Binding Cassette Transporters (ABC Transporters)IBA
12/2020 - 08/2015
3EstersIBA
01/2020 - 01/2016
3multidrug resistance-associated protein 1IBA
06/2019 - 08/2015
3AnthracyclinesIBA
02/2007 - 02/2005
2Antineoplastic Agents (Antineoplastics)IBA
01/2022 - 12/2020
2AminesIBA
01/2020 - 01/2016
2Adenosine Triphosphate (ATP)IBA
01/2019 - 08/2015
2Scopolamine (Hyoscine)FDA Link
04/2015 - 04/2011
2Verapamil (Calan)FDA LinkGeneric
11/2005 - 02/2005
1Carbonic Anhydrases (Carbonic Anhydrase)IBA
01/2022
1AmidesIBA
12/2020
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
04/2020
1tariquidar (XR9576)IBA
01/2020
1Carrier Proteins (Binding Protein)IBA
06/2019
1Protein Isoforms (Isoforms)IBA
04/2019
1CyclohexanolsIBA
01/2016
1PiperazinesIBA
04/2015
1Nootropic Agents (Nootropics)IBA
04/2015
1Pregabalin (Lyrica)FDA Link
04/2011
1Streptozocin (Streptozotocin)FDA Link
04/2011
1CyclohexaneIBA
12/2008
1Piracetam (Nootropil)IBA
12/2008
14-aminopiperidineIBA
11/2004
1N-Type Calcium Channels (N-Type Calcium Channel)IBA
11/2004
1Analgesics (Analgesic Drugs)IBA
01/2004

Therapy/Procedure

1Drug Therapy (Chemotherapy)
01/2019
1Therapeutics
01/2016